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Echinomycin is a cyclic peptide quinoxaline antibiotic used as a research reagent to probe hypoxia signaling and transcriptional regulation. It binds DNA and potently inhibits hypoxia-inducible factor-1 (HIF-1) DNA-binding activity, and has been reported to selectively affect cancer stem cell populations at low picomolar concentrations.
Potent inhibitor of HIF-1 DNA-binding activity.
High purity suitable for in vitro and cellular assays.
Stable as a solid when stored at low temperature under inert atmosphere.
Provides reproducible biological activity in hypoxia and transcription studies.
Available documentation includes datasheet and certificate of analysis.
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The protein encoded by this gene belongs to the albumin gene family It is a multifunctional protein found in plasma ascitic fluid cerebrospinal fluid and on the surface of many cell types It binds to vitamin D and its plasma metabolites and transports them to target tissues Alternatively spliced transcript variants encoding different isoforms have been found for this gene
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